First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J
ACS Omega 2020
Juris Pelss, Gints Šmits

The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compounds in a four-and five-step sequence accordingly. Flavesines G and J exhibit micromolar cytotoxicity in A549, MCF-7, HepG2, PANC-1, and HL-60 cancer cell lines.


DOI
10.1021/acsomega.0c01672
Hipersaite
https://pubs.acs.org/doi/10.1021/acsomega.0c01672

Pelss, J., Šmits, G. First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J. ACS Omega, 2020, Vol. 5, No. 21, 12568.-12572.lpp. ISSN 2470-1343. Pieejams: doi:10.1021/acsomega.0c01672

Publikācijas valoda
English (en)
RTU Zinātniskā bibliotēka.
E-pasts: uzzinas@rtu.lv; Tālr: +371 28399196