Synthetic Studies toward Novel Pyrrolobenzodiazepine–Coumarin Hybrids
Chemistry of Heterocyclic Compounds 2020
Guna Sakaine, Gints Šmits, Pavel Arsenyan

[Figure not available: see fulltext.] A comprehensive screening of known methods for the synthesis of coumarins was performed in order to obtain a new type of pyrrolobenzodiazepine–coumarin hybrids. A Pechmann condensation turned out to be the method of choice for successful synthesis of the desired hybrid starting from the corresponding phenol derivative and malic acid. Overall, the desired pyrrolobenzodiazepine–coumarin hybrid was obtained in a 3 step sequence starting from readily available starting materials – L-proline methyl ester and 4-methoxyanthranilic acid.


Atslēgas vārdi
anticancer agents, coumarin, pyrrolobenzodiazepines, pyrrolobenzodiazepine–coumarin hybrids
DOI
10.1007/s10593-020-02702-8
Hipersaite
https://link-springer-com.resursi.rtu.lv/article/10.1007%2Fs10593-020-02702-8

Sakaine, G., Šmits, G., Arsenyan, P. Synthetic Studies toward Novel Pyrrolobenzodiazepine–Coumarin Hybrids. Chemistry of Heterocyclic Compounds, 2020, Vol. 56, No. 5, 572.-577.lpp. ISSN 0009-3122. e-ISSN 1573-8353. Pieejams: doi:10.1007/s10593-020-02702-8

Publikācijas valoda
English (en)
RTU Zinātniskā bibliotēka.
E-pasts: uzzinas@rtu.lv; Tālr: +371 28399196