Fucoidan/Chitosan Hydrogels as Matrices for Sustained Delivery of Platelet-Rich Fibrin Containing Bioactive Molecules

32nd Annual Conference of the European Society for Biomaterials 2022
Karina Egle, Eva Dohle, Verena Hoffmann, Ilze Salma, Sarah Al-Maawi, Shahram Ghanaati, Arita Dubņika

To eliminate complex manufacturing procedures and still obtain a pre-seeded tissue-like construct from autologous blood, platelet-rich fibrin (PRF) was introduced. PRF is obtained from the patient's own venous blood in a single centrifugation step without the additional use of anticoagulants and contains autologous growth factors that can regulate cellular processes and tissue regeneration. The aim of this study was to determine and compare the release kinetics of different bioactive molecules from PRF and PRF/fucoidan/chitosan matrices. Fucoidan (FU) and chitosan (CS) matrices were chosen due to their biocompatibility and ability to form polyelectrolyte complexes via self-assembly.

Atslēgas vārdi
platelet rich fibrin, growth factors, histology

Egle, K., Dohle, E., Hoffmann, V., Salma, I., Al-Maawi, S., Ghanaati, S., Dubņika, A. Fucoidan/Chitosan Hydrogels as Matrices for Sustained Delivery of Platelet-Rich Fibrin Containing Bioactive Molecules. No: 32nd Annual Conference of the European Society for Biomaterials, Francija, Bordo, 4.-8. septembris, 2022. Bordo: 2022, 424.-424.lpp.

Publikācijas valoda
English (en)