The study goal was to analyze the impact of using modern technologies and pedagogical innovations based on the University 4.0 model on the educational process effectiveness, the development of professional competencies (in humanities and engineering) and skills in students (abstract-logical thinking, critical thinking, strategic thinking, imagination, creativity, motivation), and learners’ readiness and motivation to shift to University 4.0. The experiment was conducted in the Al-Farabi Kazakh National University among 464 undergraduate students of different academic years. All the study respondents were distributed into two groups, one of which did not change the training program (control group), and the other studied under the program grounded on the University 4.0 model using modern technologies (experimental group). According to the results of the survey addressed to the students of both groups after the experiment ended, the indicators for all parameters were higher among the individuals of the experimental group. The practical significance of the results obtained and further research prospects are in the possibility of using the developed training program in different universities and departments worldwide to compare both students’ readiness for the transition to University 4.0 and the program’s impact on educational outcomes.