The impact of Human and Organizational Factors (HOF) on operations and processes is already well known in many industries such as medicine and nuclear power. Ignoring HOF when organizing work with machines and mechanisms increases the possibility of risks that may arise when servicing or working. To ensure high safety performance and non-accident operation when servicing devices, more attention should be paid to HOF if it was not considered at the design stage. The importance of HOF must be considered at the initial stage of design as well as during modernization. If HOF was not considered at a sufficient level, then corrective measures to reduce the risks that arise when working with equipment are necessary. The paper shows the importance, as well as the main approaches for introducing HOF into the culture of the organization to improve safety performance. Based on the studies carried out by European and World scientists, recommendations are given to ensure the interaction of HOF with existing technical solutions, systems, and regulations with the aim of improving the working environment and increasing safety performance.