Review on the Strategies to Improve the Mechanical Strength of Highly Porous Bone Bioceramic Scaffolds

Journal of the European Ceramic Society 2024
Zahra Miri, Håvard Jostein Haugen, Dagnija Loča, Filippo Rossi, Giuseppe Perale, Amirhossein Moghanian, Qianli Ma

Bone healing is an impressive ability of the human body, but critical-sized bone defects require external inter- vention. Bioceramic scaffolds with excellent biocompatibility and bioactivity have been developed to treat non- healing bone defects because of their unique features for bone repair. Meanwhile, the mechanical properties of the material continue to be disadvantageous. This review focuses on (i) essential factors in affecting and improving bioceramic-based scaffolds’ mechanical properties, including porosity, pore size, methods, and ma- terial composition, and (ii) summarizing previous studies and highlighting strategies to fabricate scaffolds with improved mechanical properties such as using nano-particles, using a combination of bioceramics and polymers, and modifying scaffold surfaces. Further research is necessary to improve bioceramic scaffolds for bone repair applications.

Atslēgas vārdi
Mechanical properties | Bone scaffolds | Porous scaffold | Bioceramics | High-strength scaffolds
DOI
10.1016/j.jeurceramsoc.2023.09.003
Hipersaite
https://www.sciencedirect.com/science/article/pii/S095522192300688X

Miri, Z., Haugen, H., Loča, D., Rossi, F., Perale, G., Moghanian, A., Ma, Q. Review on the Strategies to Improve the Mechanical Strength of Highly Porous Bone Bioceramic Scaffolds. Journal of the European Ceramic Society, 2024, Vol. 44, No. 1, 23.-42. lpp. ISSN 0955-2219. e-ISSN 1873-619X. Pieejams: doi:10.1016/j.jeurceramsoc.2023.09.003

Publikācijas valoda
English (en)