Julia-Kocienski Olefination: A Tutorial Review

European Journal of Organic Chemistry 2023
Guna Sakaine, Zigmārs Leitis, Rebeka Ločmele, Gints Šmits

Over the past two decades, Julia-Kocienski olefination has become one of the most powerful and reliable C=C double-bond construction methods typically furnishing E-configured alkenes. This review summarizes the scientific literature of the past decade focusing on the key aspects for successful execution of the olefination step. The main stereoselectivity and yield-determining aspects have been outlined in separate chapters providing all the necessary information for the synthesis of Julia-Kocienski reagents as well as the most commonly used reaction optimization techniques.

Atslēgas vārdi
Julia-Kocienski olefination | natural products | stereoselectivity | synthetic methods | total synthesis
DOI
10.1002/ejoc.202201217
Hipersaite
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202201217

Sakaine, G., Leitis, Z., Ločmele, R., Šmits, G. Julia-Kocienski Olefination: A Tutorial Review. European Journal of Organic Chemistry, 2023, Vol. 26, No. 7, Article number e202201217. ISSN 1434-193X. Pieejams: doi:10.1002/ejoc.202201217

Publikācijas valoda
English (en)