The paper summarises the factors influencing positive financial performance (profit) in the digital age and the dynamic business environment. Based on the qualitative and quantitative literature analysis, 33 dominating financial and non-financial factors were selected, which the authors emphasize as important for sustainable and profitable business development. Web of Science-indexed research papers and a bibliometric analysis were used to assess them. The selected factors were approved and extended. A survey among Latvian businessmen was carried out to assess the practical influence of the specified factors on small and medium-sized companies. The survey involved 77 companies of various sectors and sizes. Turnover is taken as a unit to measure a company's size. In general, the businessmen evaluated the essential influence of the selected factors on the positive financial performance of small and medium-sized companies (profit). However, in additional comments, they specified risks or deeper views of the influence of the factors.