Valorization of residual brines is one of the proposed solutions for minimizing the environmental effects of desalination plants, reducing the volume of wastewater generated at the time it increases both the freshwater production and the final concentration of the residue. Nevertheless, it is an energy-demanding process: the higher the final concentration of the fluid, the higher its energy consumption. We can approach this challenge from two different perspectives, either focusing on the final amount of concentrated residue or focusing on the energy demand of the installation. In this work, the behaviour of the compressor and the variables that affect its operation in a mechanical vapor compression (MVC) desalination system are studied. Using an own develop TRNSYS model of a compressor and adjusting with a real MVC desalination plant, it is done by analysing the connections between the final volume of residual brine and its energy consumption, comparing them with the values available from the LIFE Desirows experimental facilities as well. Moreover, the paper also explores some of the environmental and economic benefits of residual brines valorization.