The replication of bone physiology under laboratory conditions is a primetarget behind the development of in vitro bone models. The model should berobust enough to elicit an unbiased response when stimulated experimentally,giving reproducible outcomes. In vitro bone tissue generation majorlyrequires the availability of cellular components, the presence of factorspromoting cellular proliferation and differentiation, efficient nutrient supply,and a supporting matrix for the cells to anchor – gaining predefined topology.Calcium phosphates (CaP) are difficult to ignore while considering the aboverequirements of a bone model. Therefore, the current review focuses on therole of CaP in developing an in vitro bone model addressing the prerequisitesof bone tissue generation. Special emphasis is given to the physico-chemicalproperties of CaP that promote osteogenesis, angiogenesis and providesufficient mechanical strength for load-bearing applications. Finally, the futurecourse of action is discussed to ensure efficient utilization of CaP in the invitro bone model development field.