Identifying the handedness of chiral molecules is of fundamental importance in chemistry, biology, pharmacy, and medicine. Nanophotonic structures allow us to control light at the nanoscale and offer powerful tools for chiral sensing, enabling the detection of small analyte volumes and low molecular concentrations by harnessing optical resonances. Most existing strategies rely on intuitive concepts such as strong local field enhancement or large local optical chirality, often achieved by engineering electric and magnetic Mie resonances in dielectric or plasmonic nanostructures. Recent insights, however, reveal that the chiroptical response of resonant systems can be governed also by less obvious mechanisms such as modal crosstalk. In this work, we present a dielectric metasurface engineered to amplify the modal crosstalk by supporting two nearly degenerate, high-quality-factor resonant states known as quasi-bound states in the continuum. Our theoretical and numerical analysis predicts a pronounced differential transmittance that exceeds the detection threshold of standard spectrometers. In particular, the differential transmittance reaches up to 10–2for the Pasteur parameter κ = 1 × 10–4. These findings advance the capabilities of nanophotonic sensors for chiral detection, paving the way toward ultrasensitive identification of molecular handedness in small volumes and concentrations within the experimentally detectable ranges.