Synthesis of Novel (1-aziridinyl-1-hydroxyiminomethyl)Arenes and Their Citotoxic Activity

Chemistry of Heterocyclic Compounds 2009
Anna Grigorjeva, Ivars Kalvinsh, Aigars Jirgensons, Ilona Dombracova, Elīna Jaščenko, Irina Šestakova, Viktors Andreanovs

The synthesis has been developed for novel potential anticancer agents whose structures contain an aziridine amidoxime group. The cytotoxic activity of all of the target compounds on different cell lines are given together with the in vitro IC50 and LD50 values found. The most promising anticancer agents were found to be the methyl 4-[1-aziridinyl(hydroxyimino)methyl]benzoate, 1-aziridinyl(2-naphthyl)-methanone oxime, and 1-aziridinyl(2-quinolyl)methanone oxime.

Atslēgas vārdi
амидоксимы, оксиимидоилхлориды, оксимы, азиридин, цитотоксическая активность.
DOI
10.1007/s10593-009-0245-3
Hipersaite
http://link.springer.com/article/10.1007/s10593-009-0245-3

Grigorjeva, A., Kalvinsh, I., Jirgensons, A., Dombracova, I., Jaščenko, E., Shestakova, I., Andreanovs, V. Synthesis of Novel (1-aziridinyl-1-hydroxyiminomethyl)Arenes and Their Citotoxic Activity. Chemistry of Heterocyclic Compounds, 2009, Vol.49, Iss.2, 203.-213.lpp. ISSN 0009-3122. e-ISSN 1573-8353. Pieejams: doi:10.1007/s10593-009-0245-3

Publikācijas valoda
English (en)