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Publikācijas valoda | English (en) |
Nosaukums oriģinālvalodā | Electrically Functionalized Hydroxyapatite and Calcium Phospate Surfaces to Enhance Immobilization and Proliferation of Osateoblasts In Vitro and Modulate Osteogenesis In Vivo |
Pētniecības nozare | 1. Dabaszinātnes |
Pētniecības apakšnozare | 1.3. Fizika un astronomija |
Autori |
Jurijs Dehtjars
M.V. Dvornichenko A.V. Karlov I.A. Khlusov Nataļja Poļaka R. Sammons K.V. Zajcevs |
Atslēgas vārdi | - |
Anotācija | Hydroxyapatite (HAP) is used to fabricate implants for bone repair in dentistry and orthopaedics. To functionalise the surface of HAP that is in direct contact with human cells a surface electrical charge deposition has been achieved by means of hydrogenation technology. This technology provides uniform 3 dimensioned processing of the specimen surfaces. The engineered charge was estimated from measurements of the photoelectron emission work function (ϕ). The later was increased to ~ 0.2 eV. The negatively charged HAP surface attached 10 times more osteoblatic cells and increased their proliferation capacity 1.6 times, in contrast to the uncharged one. The above increment of ϕ had an effect on the differentiation of mesenchymal stromal cell pool (MSCP) immobilized on the calcium phosphate (CP) coatings. In vivo experiments (BALB/c mice) demonstrated that hydrogenation of CP coatings could effect MSCP differentiation into fibroblasts or osteoblasts. The technique of intracellular RNA staining detected the actively synthesizing osteoblasts and bone marrow stromal cells. |
DOI: | 10.1007/978-3-642-03900-3_70 |
Hipersaite: | http://link.springer.com/chapter/10.1007/978-3-642-03900-3_70 ![]() |
Atsauce | Dehtjars, J., Dvornichenko, M., Karlov, A., Khlusov, I., Poļaka, N., Sammons, R., Zajcevs, K. Electrically Functionalized Hydroxyapatite and Calcium Phospate Surfaces to Enhance Immobilization and Proliferation of Osateoblasts In Vitro and Modulate Osteogenesis In Vivo. No: IFMBE Proceedings. Vol.25/10: World Congress on Medical Physics and Biomedical Engineering, Vācija, Munich, 7.-12. septembris, 2009. Berlin: Springer Berlin Heidelberg, 2010, 245.-248.lpp. ISBN 978-3-642-03899-0. e-ISBN 978-3-642-03900-3. ISSN 1680-0737. Pieejams: doi:10.1007/978-3-642-03900-3_70 |
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ID | 6841 |