Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

Dace Rasiņa, M. Otikovs, J. Leitans, R. Recacha, O. Borysov, I. Kanepe-Lapsa, I. Domraceva, T. Pantelejevs, K. Tars, M. Blackman, Kristaps Jaudzems, Aigars Jirgensons

Representative spectra from NMR based fragment screening; X-ray structure descriptors, description of synthesis for amines 7b–g and pinacolborates 13a–d,f–l

Date
15.12.2015.
Keywords
Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV
DOI
10.1021/acs.jmedchem.5b01558
Hyperlink
https://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.5b01558