RTU Research Outputs and Resources: Reasearch Staff

Information about Author

Name, Surname:

Aigars Jirgensons

Department:

(32300) Ķīmijas un ķīmijas tehnoloģijas institūts

Scientific Degree:

Doktors

E-mail:

Aigars.Jirgensons(at)rtu.lv

Publications

132 items found, displaying 1 to 10.

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Jekaterina Boļšakova, Raitis Bobrovs, Larisa Varacheva, Anastasija Rudnickiha, Iveta Kaņepe, Emilio Parisini, Aigars Jirgensons
Scientific article indexed in SCOPUS or WOS database

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
(2023)

Raitis Bobrovs, Laura Drunka, Iveta Kaņepe, Aigars Jirgensons, Amedeo Caflisch, Matteo Salvalaglio, Kristaps Jaudzems
Scientific article indexed in SCOPUS or WOS database

Semisynthesis of Linariophyllenes A-C and Rumphellolide H, Structure Revisions and Proposed Biosynthesis Pathways
(2023)

Georgijs Stakanovs, Anastasija Blazevica, Sergey Belyakov, Dace Rasiņa, Aigars Jirgensons
Scientific article indexed in SCOPUS or WOS database

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
(2023)

Vadims Kovada, Chrislaine Withers-Martinez, Raitis Bobrovs, Helēna Cīrule, Edgars Liepiņš, Solveiga Grinberga, Fiona Hackett, Christine R. Collins, Agrita Kreicberga, Maria Belen Jimez-Diaz, Inigo Angulo-Barturen, Dace Rasiņa, Edgars Sūna, Kristaps Jaudzems, Michael J. Blackman, Aigars Jirgensons
Scientific article indexed in SCOPUS or WOS database

Assembling the Methanoindene Cage of Phragmalin-Type Natural Products
(2023)

Joseph Becica, Olavs Rāciņš, Marija Ivanova, Aigars Jirgensons
Scientific article indexed in SCOPUS or WOS database

Synthesis and Evaluation of an Agrocin 84 Toxic Moiety (TM84) Analogue as a Malarial Threonyl tRNA Synthetase Inhibitor
(2023)

Jhon Alexander Rodriguez Buitrago, Gundars Leitis, Iveta Kaņepe-Lapsa, Anastasija Rudnickiha, Emilio Parisini, Aigars Jirgensons
Scientific article indexed in SCOPUS or WOS database

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
(2023)

Olga Bobileva, Raitis Bobrovs, Evelīna Elva Sirma, Iveta Kaņepe, Anna L. Bula, Liene Patetko, Anna Ramata-Stunda, Solveiga Grinberga, Aigars Jirgensons, Kristaps Jaudzems
Scientific article indexed in SCOPUS or WOS database

Effect of Novel Furan-Based Ester Reactive Diluent on Structure and Properties of UV-Crosslinked Acrylated Rapeseed Oil
(2023)

Sabīne Briede, Oskars Platnieks, Madara Dārziņa, Aigars Jirgensons, Sergejs Gaidukovs
Scientific article indexed in SCOPUS or WOS database

Synthesis and SAR of Phenylazoles, Active Against Staphylococcus Aureus Newman
(2023)

Vitalii Solomin, Blanca Fernandez Ciruelos, Nadya Velikova, Jerry Wells, Marco Albanese, Adhav Anmol, Aigars Jirgensons
Scientific article indexed in SCOPUS or WOS database

Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery
(2022)

Elīna Līdumniece, Chrislaine Withers-Martinez, Fiona Hackett, Michael J Blackman, Aigars Jirgensons
Scientific article indexed in SCOPUS or WOS database

Information about Author

Publications

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
(2023)

Semisynthesis of Linariophyllenes A-C and Rumphellolide H, Structure Revisions and Proposed Biosynthesis Pathways
(2023)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
(2023)

Assembling the Methanoindene Cage of Phragmalin-Type Natural Products
(2023)

Synthesis and Evaluation of an Agrocin 84 Toxic Moiety (TM84) Analogue as a Malarial Threonyl tRNA Synthetase Inhibitor
(2023)

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
(2023)

Effect of Novel Furan-Based Ester Reactive Diluent on Structure and Properties of UV-Crosslinked Acrylated Rapeseed Oil
(2023)

Synthesis and SAR of Phenylazoles, Active Against Staphylococcus Aureus Newman
(2023)

Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery
(2022)

Supervised Dissertations

Development of Scalable Synthesis for Selected Serine Protease uPA Inhibitors
(2023)

Development of New Synthetic Methods based on Electrochemical Oxidation of Stannylmethylethers and Furan Derivatives
(2023)

Development of Malarial Enzyme Inhibitors
(2023)

The Development of New Methods for the Synthesis of PLP-Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-Acetylserine Sulfhydrylase
(2023)

New Methods for the Synthesis and C–H Functionalization of Amino Alcohols
(2020)

Electrophile-Induced Cyclopropane Reactions with Nucleophiles
(2018)

Development of Malarial Aspartic Protease Inhibitors
(2016)

Development of Malarial Protease PfSUB1 Inhibitors
(2014)

C-Heteroatom Bond Formation In Lewis Acid Catalysed Allylic Substitution Reaction
(2013)

Projects

Atbalsts RTU doktora studiju īstenošanai - 2
Izglītība

Methods of critical infrastructure control
Enerģētika

Information about Author

Publications

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library (2024)

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors (2023)

Semisynthesis of Linariophyllenes A-C and Rumphellolide H, Structure Revisions and Proposed Biosynthesis Pathways (2023)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity (2023)

Assembling the Methanoindene Cage of Phragmalin-Type Natural Products (2023)

Synthesis and Evaluation of an Agrocin 84 Toxic Moiety (TM84) Analogue as a Malarial Threonyl tRNA Synthetase Inhibitor (2023)

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors (2023)

Effect of Novel Furan-Based Ester Reactive Diluent on Structure and Properties of UV-Crosslinked Acrylated Rapeseed Oil (2023)

Synthesis and SAR of Phenylazoles, Active Against Staphylococcus Aureus Newman (2023)

Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery (2022)

Supervised Dissertations

Development of Scalable Synthesis for Selected Serine Protease uPA Inhibitors (2023)

Development of New Synthetic Methods based on Electrochemical Oxidation of Stannylmethylethers and Furan Derivatives (2023)

Development of Malarial Enzyme Inhibitors (2023)

The Development of New Methods for the Synthesis of PLP-Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-Acetylserine Sulfhydrylase (2023)

New Methods for the Synthesis and C–H Functionalization of Amino Alcohols (2020)

Electrophile-Induced Cyclopropane Reactions with Nucleophiles (2018)

Development of Malarial Aspartic Protease Inhibitors (2016)

Development of Malarial Protease PfSUB1 Inhibitors (2014)

C-Heteroatom Bond Formation In Lewis Acid Catalysed Allylic Substitution Reaction (2013)

Projects

Atbalsts RTU doktora studiju īstenošanai - 2 Izglītība

Methods of critical infrastructure control Enerģētika

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
(2023)

Semisynthesis of Linariophyllenes A-C and Rumphellolide H, Structure Revisions and Proposed Biosynthesis Pathways
(2023)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
(2023)

Assembling the Methanoindene Cage of Phragmalin-Type Natural Products
(2023)

Synthesis and Evaluation of an Agrocin 84 Toxic Moiety (TM84) Analogue as a Malarial Threonyl tRNA Synthetase Inhibitor
(2023)

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
(2023)

Effect of Novel Furan-Based Ester Reactive Diluent on Structure and Properties of UV-Crosslinked Acrylated Rapeseed Oil
(2023)

Synthesis and SAR of Phenylazoles, Active Against Staphylococcus Aureus Newman
(2023)

Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery
(2022)

Development of Scalable Synthesis for Selected Serine Protease uPA Inhibitors
(2023)

Development of New Synthetic Methods based on Electrochemical Oxidation of Stannylmethylethers and Furan Derivatives
(2023)

Development of Malarial Enzyme Inhibitors
(2023)

The Development of New Methods for the Synthesis of PLP-Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-Acetylserine Sulfhydrylase
(2023)

New Methods for the Synthesis and C–H Functionalization of Amino Alcohols
(2020)

Electrophile-Induced Cyclopropane Reactions with Nucleophiles
(2018)

Development of Malarial Aspartic Protease Inhibitors
(2016)

Development of Malarial Protease PfSUB1 Inhibitors
(2014)

C-Heteroatom Bond Formation In Lewis Acid Catalysed Allylic Substitution Reaction
(2013)

Atbalsts RTU doktora studiju īstenošanai - 2
Izglītība

Methods of critical infrastructure control
Enerģētika