Semisynthesis of Exotic Terpenoids from (–)-β-Caryophyllene
2024
Georgijs Stakanovs

Defending
12.12.2024. 14:00, Rīga, Paula Valdena iela 3, 272. auditorija

Supervisor
Aigars Jirgensons, Dace Rasiņa

Reviewers
Pāvels Arsenjans, Karl-Heinz Altmann, Tõnis Kanger

The Thesis describes the development of synthetic methods towards exotic marine and terrestrial natural products from β-caryophyllene. Due to its wide availability in enantiopure form, β-caryophyllene and its oxide were used in the Thesis to obtain biologically active and structurally complex terpenoids. The established synthetic routes enabled the preparation of final compounds up to gram scale as well as allowed for the structure confirmation/revision and the proposal of biosynthetic pathways of target terpenoids. The structures of the final products were unambiguously determined by single-crystal X-ray diffractometry.


Keywords
Dabasvielas, terpenoīdi, β‑kariofilēns
DOI
10.7250/9789934371226

Stakanovs, Georgijs. Semisynthesis of Exotic Terpenoids from (–)-β-Caryophyllene. PhD Thesis. Rīga: [RTU], 2024. 89 p.

Publication language
Latvian (lv)
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