Synthesis of 2-Arylquinazolines by Chan–Evans–Lam Coupling of 2-Formylphenylboronic Acids with Amidines

Chemistry of Heterocyclic Compounds 2024
Vitalii Solomin, Darija Zaharova, Aigars Jirgensons

(Figure presented.) A method for the synthesis of 2-arylquinazolines is described which involves Chan–Evans–Lam coupling of 2-formylphenylboronic acids with amidines. The reaction is performed at mild conditions compatible with the range of functional groups and is cost-efficient, provided by usage of inexpensive catalyst and reagents. The synthesis method of 2-arylquinazolines presented is of with scope in both 2-formylphenylboronic acids and amidines.

Keywords
amidines | arylquinazolines | Chan–Evans–Lam coupling | copper catalysis | heterocyclization
DOI
10.1007/s10593-024-03314-2
Hyperlink
https://link.springer.com/article/10.1007/s10593-024-03314-2

Solomin, V., Zaharova, D., Jirgensons, A. Synthesis of 2-Arylquinazolines by Chan–Evans–Lam Coupling of 2-Formylphenylboronic Acids with Amidines. Chemistry of Heterocyclic Compounds, 2024, Vol. 60, No. 3-4, pp.169-174. ISSN 0009-3122. e-ISSN 1573-8353. Available from: doi:10.1007/s10593-024-03314-2

Publication language
English (en)