N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors

M. Charlton, R. Aleksis, A. Saint-Leger, A. Gupta, E. Loza, L. Ribas De Pouplana, I. Kaula, D. Gustina, M. Madre, D. Lola, Kristaps Jaudzems, G. Edmund, L. Kime, A. O`Neill, W. Goessens, Aigars Jirgensons, P. Finn

Synthesis and characterization of compound 7; description of molecular modeling; ITC titration curves; description of enzymatic assay and antimicrobial susceptibility

Date
18.01.2018.
Keywords
N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors
DOI
10.1021/acsmedchemlett.7b00374
Hyperlink
https://pubs.acs.org/doi/suppl/10.1021/acsmedchemlett.7b00374