Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids

ChemInform 2011
Liene Grigorjeva, Aigars Jirgensons

(E)-Alkenyloxazolines and -oxazines are effectively prepared from both (E)- or (Z)-bis(trichloroacetimidates) in the presence of a variety of Lewis acid catalysts (TmsOTf, FeCl3, AlCl3, BF3·OEt2, TosOH) in general within minutes.

Keywords
ring closure reactions; oxazine derivatives; oxazole derivatives; aminocarboxylic acids (hydrazinocarboxylic acids) and esters (acyclic compounds); aminocarboxylic acids (hydrazinocarboxylic acids) and esters (benzene compounds)
DOI
10.1002/chin.201135039
Hyperlink
http://dx.doi.org/10.1002/chin.201135039

Grigorjeva, L., Jirgensons, A. Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids. ChemInform, 2011, Vol.42, Iss.35, pp.39-39. ISSN 1522-2667. Available from: doi:10.1002/chin.201135039

Publication language
English (en)