High-speed machining is an effective modern machining method used in die-cast material processing, to increase the efficiency, quality and accuracy of the machined surface and to reduce costs and machining time. The aim of this research is to explore the technological strategy and influence of the processed materials on the 3D surface roughness parameters and provide recommendations for manufacturers on how to obtain the prescribed surface roughness parameters. This paper covers analysis of the following factors: feed rate, manufacturing strategy, overlap and material influences on the most characteristic 3D surface parameters. The results are based on ANOVA—analysis of variance—where differences between groups of means are analysed using a collection of statistical models. This method enables the comparison of three or more group variables for statistical significance. The present paper provides analysis and relevant conclusions on the most significant impact factors: material and the high-speed milling manufacturing strategy.