Brain-Machine-Interfaces and mind controlled manipulators are no longer science fiction. It is time to go even further. The functionality of hand prosthesis and manipulators is limited by the availability of sensory information about features of grasped object and manipulative forces. Artificial sensors, which could match functionality of human tactile receptors, currently are not available. Aims of the study.1. Using neurophysiological knowledge about functional properties of human tactile afferents and use of sensory information in sensorimotor transformations during object manipulation acknowledge obstacles which have precluded engineers from developing highly efficient artificial sensors. 2. Define requirements crucial for building artificial tactile sensors mimicking biological prototype. 3. To test mechanical features and evaluate stimulus-response characteristics of unique mechanosensitive conductive rubber material developed by our material science team. Materials and Methods.Mechanosensitive conductive rubber was manufactured by blending polyisoprene caoutchoucwith highly structured nano–size carbon black (Degussa Printex XE2), Cyclohexyl-Benzothiazole-Sulfenamide, zinc oxide and sulphur. Results.Mechanosensitive conductive rubber demonstrated high sensitivity to deformation, feature stability across relevant environmental conditions and ability to respond to fast dynamic stimuli in the frequency range of up to 50Hz, which matches features of biological type of receptors involved in signalling frictional information. Frictional information is the key parameter required to control grip forces during object manipulation. Conclusions. Our mechanosensitive conductive rubber demonstrated unique combination of features like sensitivity to deformation (bending and stretch) and softness which makes it exceptionally suitable for manufacturing artificial tactile sensors to be used in intelligent hand prosthesis and robotic manipulators.