Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1

Chemistry of Heterocyclic Compounds 2015
Samir Satish Kher, M. Penzo, S. Fulle, J. P. Ebejer, P. W. Finn, M. J. Blackman, Aigars Jirgensons

2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure-activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1.

Keywords
inhibitors, malaria, Malaria Box, PfSUB1 protease, quinoxaline
DOI
10.1007/s10593-014-1610-4
Hyperlink
http://link.springer.com/article/10.1007%2Fs10593-014-1610-4

Kher, S., Penzo, M., Fulle, S., Ebejer, J., Finn, P., Blackman, M., Jirgensons, A. Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1. Chemistry of Heterocyclic Compounds, 2015, Vol.50, Iss.10, pp.1456-1462. ISSN 0009-3122. e-ISSN 1573-8353. Available from: doi:10.1007/s10593-014-1610-4

Publication language
English (en)