Development of Magnesium Modified Calcium Phosphate Bioceramic for Bone Tissue Regeneration
2016
Līga Stīpniece

Defending
14.12.2016. 13:00, Rīgas Tehniskās universitātes Materiālzinātnes un lietišķās ķīmijas fakultātē, Paula Valdena ielā 3/7, 272. auditorijā.

Supervisor
Līga Bērziņa-Cimdiņa, Kristīne Šalma-Ancāne

Reviewers
Remo Merijs-Meri, Juta Kroiča, Bikramjit Basu

Calcium phosphate bioceramics precursor powders of hydroxyapatite, calcium deficient hydroxyapatite and apatitic tricalcium phosphate containing various amounts of magnesium were synthesized through modified aqueous precipitation method. The influence of magnesium content on the physicochemical properties of the precursor powders was analysed. The potential of magnesium containing calcium phosphates precursor powders for preparation of dense and porous bioceramic with variable and reproducible chemical and phase composition were investigated. For the first time porous magnesium containing calcium phosphates, i.e., hydroxyapatite and β-tricalcium phosphate, bioceramic were formed by the ammonium hydrogen carbonate provided viscous slurry foaming. The chemical and phase composition, molecular structure, morphology and microstructure of obtained magnesium containing calcium phosphates products, as well as the influence of magnesium on the thermal stability and sintering processes were analysed using a wide range of advanced research methods. For the first time systematic and complex studies of coherence between the various combinations of hydroxyapatite/β-tricalcium phosphate phase ratio and magnesium content on biological properties of calcium phosphate bioceramic were performed. The most recent milestones in the research of calcium phosphates for biomedical applications as well as potential of magnesium containing calcium phosphates bioceramic for bone tissue regeneration applications are highlighted in the literature review. The Doctoral thesis is written in the Latvian language, consist of 141 pages. The Doctoral Thesis has been illustrated by 48 figures and 22 tables. List of References comprises 224 information sources.


Keywords
BIOKERAMIKA, MAGNIJS, DIVFĀŽU KALCIJA FOSFĀTI, HIDROKSILAPATĪTS, β-TRIKALCIJA FOSFĀTS

Stīpniece, Līga. Development of Magnesium Modified Calcium Phosphate Bioceramic for Bone Tissue Regeneration. PhD Thesis. Rīga: [RTU], 2016. 141 p.

Publication language
Latvian (lv)
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