X-Ray Crystallography-Promoted Drug Design of Carbonic Anhydrase Inhibitors
Chemical Communications
2015
Jekaterīna Ivanova,
Raivis Žalubovskis,
Muhammet Tanc,
Andris Kazaks,
Claudiu T. Supuran,
Kaspars Tārs,
Janis Leitans
1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications. This journal is
DOI
10.1039/c5cc01854d
Hyperlink
http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC01854D#!divAbstract
Ivanova, J., Žalubovskis, R., Tanc, M., Kazaks, A., Supuran, C., Tārs, K., Leitans, J. X-Ray Crystallography-Promoted Drug Design of Carbonic Anhydrase Inhibitors. Chemical Communications, 2015, Vol.51, pp.7108-7111. ISSN 1359-7345. Available from: doi:10.1039/c5cc01854d
Publication language
English (en)