Synthesis of Indazoles from 2-Formylphenylboronic Acids
RSC Advances 2021
Vitalii Solomin, A Šeins, Aigars Jirgensons

A method for the synthesis of indazoles was developed which involves a copper(ii) acetate catalysed reaction of 2-formylboronic acids with diazadicaboxylates followed by acid or base induced ring closure. Hydrazine dicarboxylates were also shown as competent reaction partners for the synthesis of indazoles, however, they required a stoichiometric amount of copper(ii) acetate for the C-N bond formation step. The transformation can be efficiently performed as a two step-one pot procedure to give a range of 1N-alkoxycarbonyl indazoles.


Keywords
1H-INDAZOLES; DERIVATIVES; EFFICIENT; ARYNES
DOI
10.1039/d1ra04056a
Hyperlink
https://pubs.rsc.org/en/content/articlelanding/2021/RA/D1RA04056A

Solomin, V., Šeins, A., Jirgensons, A. Synthesis of Indazoles from 2-Formylphenylboronic Acids. RSC Advances, 2021, Vol. 11, No. 37, pp.22710-22714. ISSN 2046-2069. Available from: doi:10.1039/d1ra04056a

Publication language
English (en)
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