The aim of the study was to prepare drug-loaded calcium phosphate bone cements (CPC) and to analyze the effect of drug type influence on the drug release kinetics of prepared cements. For CPC preparation 𝛼-tricalcium phosphate (𝛼-TCP) synthesized at 650o C was used as the solid phase, and 1 M Na salt solution was used as the liquid phase. Such drugs as doxorubicin hydrochloride (DOX), lidocaine hydrochloride monohydrate (LidHCl), dexamethasone sodium phosphate (DEXA) and vancomycin hydrochloride (VAN) were added to the solid phase of CPC to obtain local drug delivery systems. Obtained results revealed that the release kinetics of all prepared CPCs is characterized by burst release in the first 24 hours followed by a sustained release over 7 day period. DOX-loaded CPCs demonstrated the lowest drug content released, which could be explained by the possible interaction between the functional groups of the drug and the cement matrix, which can lead to the formation of Ca-DOX complexes that can delay the drug release.