Synthesis and SAR of Phenylazoles, Active Against Staphylococcus Aureus Newman

Chemistry of Heterocyclic Compounds 2023
Vitalii Solomin, Blanca Fernandez Ciruelos, Nadya Velikova, Jerry Wells, Marco Albanese, Adhav Anmol, Aigars Jirgensons

[Figure not available: see fulltext.] Series of new potent inhibitors of growth of Staphylococcus aureus Newman, based on 3,4-diphenylpyrazole and 4,5-diphenylisoxazole derivatives were discovered. Structures of interest were selectively modified to check their structure–activity relationship. Studies revealed the most essential groups in the molecule for the antimicrobial activity retention. Active compounds with good MIC range should contain both nonpolar aromatic residues and hydrogen bond donating groups. The best MIC results in selected cases were lower than 1 μg/ml.

Keywords
antimicrobial activity | diphenylazole | isoflavone | isoxazole | pyrazole | Staphylococcus aureus Newman
DOI
10.1007/s10593-023-03151-9
Hyperlink
https://link.springer.com/article/10.1007/s10593-023-03151-9

Solomin, V., Ciruelos, B., Velikova, N., Wells, J., Albanese, M., Anmol, A., Jirgensons, A. Synthesis and SAR of Phenylazoles, Active Against Staphylococcus Aureus Newman. Chemistry of Heterocyclic Compounds, 2023, Vol. 58, No. 12, pp.737-748. ISSN 0009-3122. e-ISSN 1573-8353. Available from: doi:10.1007/s10593-023-03151-9

Publication language
English (en)