Octacalcium Phosphate Phase Forming Cements as an Injectable Bone Substitute Materials: Preparation and in vitro Structural Study
Biomaterials Advances 2024
Oznur Demir, Athanasia Pylostomou, Dagnija Loča

In the realm of regenerating damaged or degenerated bones through minimally invasive techniques, injectable materials have emerged as exceptionally promising. Among these, calcium phosphate bone cements (CPCs) have garnered significant interest due to their remarkable bioactivity, setting it apart from non-degradable alterna- tives such as polymethyl methacrylate cements. α-Tricalcium phosphate (α-TCP) is a widely used solid phase component in CPCs. It can transform into calcium-deficient hydroxyapatite (CDHAp) when it comes in contact with water. In this study, we aimed to create an injectable, self-setting bone cement using low-temperature synthesized α-TCP powder as a single precursor of the powder phase. We found that changes in the pH of the liquid phase (pH 6.0, pH 6.2, pH 7.0 and pH 7.4) significantly altered the cement’s setting, handling, and me- chanical properties. The formation of the octacalcium phosphate (OCP) phase was identified in our study, which positively affects the osteoblastic cell response. Hardened OCP-forming bone cements prepared using a liquid phase with pH 7.0 and 7.4 showed better osteogenic cell attachment and proliferation than those prepared with pH 6.0 and 6.2. Our study suggests that changes in the pH of the liquid phase can significantly affect the properties of α-TCP-based bone cement, and the presence of the OCP phase is crucial for optimal cement performance.


Keywords
Octacalcium phosphate, Calcium phosphate bone cements, Calcium phosphate, Preosteoblast cells, Bone regeneration
DOI
10.1016/j.bioadv.2023.213731
Hyperlink
https://www.sciencedirect.com/science/article/pii/S2772950823004545?via%3Dihub

Demir, O., Pylostomou, A., Loča, D. Octacalcium Phosphate Phase Forming Cements as an Injectable Bone Substitute Materials: Preparation and in vitro Structural Study. Biomaterials Advances, 2024, Vol. 157, Article number 213731. ISSN 2772-9516. e-ISSN 2772-9508. Pieejams: doi:10.1016/j.bioadv.2023.213731

Publication language
English (en)
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