Drug Infiltration in Porous Hydroxyapatite Ceramic and Tissue Response

Integrated Ferroelectrics 2008
Līga Bērziņa-Cimdiņa, Rita Seržāne, Andrejs Skagers, Ilze Salma, Māra Pilmane, girts Salms

Sintered porous hydroxyapatite (HAp) ceramics were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), optical and scanning electron microscopy (SEM). The samples were saturated with dexamethasone solution (1 mg/ml) or lidocaine solution (5 mg/ml) using vacuum method. To evaluate early reactogenity of porous synthetic impregnated HAp ceramic implants were inserted in holes of rabbit's lower jaws for 2 weeks, 1 month and 3 months. Immunohistochemical methods for evaluation of growth factors and apoptosis were applied. This study aims to further comprehension of reactogenicity of HAp bioceramic implants as bone substitutes in subperiostal environment

Keywords
Bioceramics; Hydroxyapatite; Implantation; Porous material
DOI
10.1080/10584580802558225
Hyperlink
http://www.tandfonline.com/doi/abs/10.1080/10584580802558225#.Uv87imxWE5s

Bērziņa-Cimdiņa, L., Seržāne, R., Skagers, A., Salma, I., pilmane, M., salms, g. Drug Infiltration in Porous Hydroxyapatite Ceramic and Tissue Response. Integrated Ferroelectrics, 2008, Vol.103, Iss.1, pp.66-71. e-ISSN 1607-8489. ISSN 1058-4587. Available from: doi:10.1080/10584580802558225

Publication language
English (en)