Due to excellent biocompatibility with living body and bioactivity, calcium phosphates (CaP) are widely used as biomedical implant materials [1]. Biomaterials and bioceramic made of calcium phosphates are produced in different forms: granules, blocks (dense or porous), injectable compositions, self-hardening cements, coatings on metallic implants, composites from polymers, and so forth [2]. Hydroxyapatite (HAp) is thermodynamically the most stable phase in physiological conditions and has the ability to form direct chemical bonding with living tissues. In this work hydroxyapatite was synthesized by modified wet chemical precipitation route. Contrary to the conventional chemical precipitation route calcium hydroxide suspension was homogenized in planetary mill. Milling calcium oxide and water in planetary ball mill as a first step of synthesis provides a highly dispersed calcium hydroxide suspension. The aim of this work was to explore the influence of preparation methodology of calcium hydroxide suspension, its morphology on the physico-chemical characteristics of HAp suspension. These characteristics are very important because the final product morphology and consequently microstructure of hydroxyapatite bioceramics after thermal treatment. Fourier-transform infrared spectroscopy, X-ray diffraction, and Field Emission Scanning Electron Microscopy were used to investigate starting materials of synthesis, synthesized powders and sintered bioceramic samples. Synthesized hydroxyapatite powders from different Ca sources have different morphology and crystal size. This affects hydroxyapatite bioceramic microstructure and sintering behaviour. The morhhological features of the calcium hydroxide suspension greatly influence the quality of the synthesis product.