Control of Setting Time of α-Tricalcium Phosphate Bone Cements Using Liquid Phase Additives

The Summit of European Orthopaedic Research: The Conference of the European Orthopaedic Research Society 2010
Zilgma Irbe, Linda Vecbiškena, Līga Bērziņa-Cimdiņa

In this work the effect of three liquid phase additives on setting of α-tricalcium phosphate (α-TCP) at near neutral pH is investigated. These additives are pyrophosphate, tartrate and citrate ions. α-TCP cements set by solution of α-TCP and subsequent precipitation of calcium deficient hydroxyapatite. By using liquid phase additives it is possible to control the setting time of α-TCP cements at near neutral pH (6 – 8). Investigated additives retard initial HAp formation. The nature of setting time modification (acceleration/retardation) is dependent on the initial pH and additive concentration in the liquid phase.

Keywords
biomaterials, calcium phosphates, calcium phosphate cements

Irbe, Z., Vecbiškena, L., Bērziņa-Cimdiņa, L. Control of Setting Time of α-Tricalcium Phosphate Bone Cements Using Liquid Phase Additives. In: The Summit of European Orthopaedic Research: The Conference of the European Orthopaedic Research Society, Switzerland, Davos, 30 Jun-2 Jul., 2010. Davos: European Orthopaedic Research Society, 2010, pp.P-0016-P-0016.

Publication language
English (en)