Synthesis of compounds 4, 8 - 11 ................................ ................................ ................................ . 2 2. Copies of 1 H - NMR and 13 C - NMR spectra for compounds 4, 8 - 11 ................................ .......... 20 3. PfThrRS Protein expression and purification ................................ ................................ ........... 39 4. Determination of PfThrRS inhibitory potency ................................ ................................ ......... 39 5. ITC Studies for compound binding to Human ThrRS ................................ .............................. 41