RTU Zinātniskās darbības rezultāti un resursi: Personāls

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Jekaterina Boļšakova, Raitis Bobrovs, Larisa Varacheva, Anastasija Rudnickiha, Iveta Kaņepe, Emilio Parisini, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors
(2024)

Gints Kalniņš, Laura Ruduša, Anna L. Bula, Diāna Zeļencova-Gopejenko, Olga Bobiļeva, Mihails Sisovs, Kaspars Tārs, Aigars Jirgensons, Kristaps Jaudzems, Raitis Bobrovs
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors
(2024)

Raitis Bobrovs, Jekaterina Boļšakova, Jhon Alexander Rodriguez Buitrago, Larisa Varanceva, Marija Skvorcova, Iveta Kaņepe, Anastasija Rudnickiha, Emilio Parisini, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Discovery and Optimisation of Pyrazolo[1,5-a]Pyrimidines as Aryl Hydrocarbon Receptor Antagonists
(2024)

Raitis Bobrovs, Svetlana Terentjeva, Ninne Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, jason Matthews, Kristaps Jaudzems
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
(2023)

Raitis Bobrovs, Laura Ruduša, Iveta Kaņepe, Aigars Jirgensons, Amedeo Caflisch, Matteo Salvalaglio, Kristaps Jaudzems
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
(2023)

Vadims Kovada, Chrislaine Withers-Martinez, Raitis Bobrovs, Helēna Cīrule, Edgars Liepiņš, Solveiga Grinberga, Fiona Hackett, Christine R. Collins, Agrita Kreicberga, Maria Belen Jimez-Diaz, Inigo Angulo-Barturen, Dace Rasiņa, Edgars Sūna, Kristaps Jaudzems, Michael J. Blackman, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
(2023)

Olga Bobileva, Raitis Bobrovs, Evelīna Elva Sirma, Iveta Kaņepe, Anna L. Bula, Liene Patetko, Anna Ramata-Stunda, Solveiga Grinberga, Aigars Jirgensons, Kristaps Jaudzems
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Exploring Aspartic Protease Inhibitor Binding to Design Selective Antimalarials
(2022)

Raitis Bobrovs, Emīls Edgars Basens, Laura Drunka, Iveta Kanepe, Sofija matisone, Karlis Kristofers Velins, Victor Andrianov, Gundars Leitis, Diāna Zeļencova-Gopejenko, Dace Rasiņa, Aigars Jirgensons, Kristaps Jaudzems
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Synthesis of 2-Aminopyridopyrimidinones and Their Plasmepsin I, II, IV Inhibition Potency
(2020)

Dace Rasiņa, Georgijs Stakanovs, Iveta Kaņepe-Lapsa, Raitis Bobrovs, Kristaps Jaudzems, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Informācija par autoru

Publikācijas

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors
(2024)

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors
(2024)

Discovery and Optimisation of Pyrazolo[1,5-a]Pyrimidines as Aryl Hydrocarbon Receptor Antagonists
(2024)

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
(2023)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
(2023)

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
(2023)

Exploring Aspartic Protease Inhibitor Binding to Design Selective Antimalarials
(2022)

Synthesis of 2-Aminopyridopyrimidinones and Their Plasmepsin I, II, IV Inhibition Potency
(2020)

Informācija par autoru

Publikācijas

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library (2024)

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors (2024)

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors (2024)

Discovery and Optimisation of Pyrazolo[1,5-a]Pyrimidines as Aryl Hydrocarbon Receptor Antagonists (2024)

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors (2023)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity (2023)

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors (2023)

Exploring Aspartic Protease Inhibitor Binding to Design Selective Antimalarials (2022)

Synthesis of 2-Aminopyridopyrimidinones and Their Plasmepsin I, II, IV Inhibition Potency (2020)

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors
(2024)

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors
(2024)

Discovery and Optimisation of Pyrazolo[1,5-a]Pyrimidines as Aryl Hydrocarbon Receptor Antagonists
(2024)

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
(2023)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
(2023)

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
(2023)

Exploring Aspartic Protease Inhibitor Binding to Design Selective Antimalarials
(2022)

Synthesis of 2-Aminopyridopyrimidinones and Their Plasmepsin I, II, IV Inhibition Potency
(2020)