New Approach to the Synthesis of Triazolyl Purine Nucleosides

Abstracts of Riga Technical University 54th International Scientific Conference : Section: Material Science and Applied Chemistry 2013
Irina Novosjolova, Madara Bārzdaine, Ērika Bizdēna, Sergejs Beļakovs, Māris Turks

A straightforward way to synthesis of 2,6-bis-(1,2,3-triazol-1-yl)-purine nucleosides has been developed from 2,6-diazidopurine nucleosides and various terminal alkynes. We have discovered that triazolyl moiety at C(6) of the purine base undergoes a facile heteroaromatic nucleophilic substitution with variety of N- and S-nucleophiles.

Atslēgas vārdi
Purine nucleosides, 2,6-bis-triazolyl purine derivatives, 1,3-dipolar cycloaddition, nucleophilic aromatic substitution, fluorescence

Novosjolova, I., Bārzdaine, M., Bizdēna, Ē., Beļakovs, S., Turks, M. New Approach to the Synthesis of Triazolyl Purine Nucleosides. No: Abstracts of Riga Technical University 54th International Scientific Conference : Section: Material Science and Applied Chemistry, Latvija, Riga, 14.-16. oktobris, 2013. Riga: RTU Press, 2013, 35.-35.lpp. ISBN 9789934104640.

Publikācijas valoda
English (en)