A Synthetic Route to 2,6-Bis-triazolyl Purine Deoxynucleosides via Click Chemistry
16th Symposium on Chemistry of Nucleic Acid Components: Collection Symposium Series (M.Hocek, Ed.)
2014
Dace Cīrule,
Kristers Ozols,
Irina Novosjolova,
Māris Turks,
Ērika Bizdēna
3',5'-O-Protected 2,6-diazidopurine deoxynucleosides have been obtained in multistep synthesis either from deoxyguanosine or by direct glycosylation of diazidopurine sodium salt. In the latter case, X-ray analysis confirms b-configuration and diazido tautomeric form of the obtained glycosylated diazidopurine. In click reaction the series of 2,6-bis(4-substituted-1,2,3-triazol-1-yl)purine deoxynucleosides were synthesized.
Atslēgas vārdi
purine nucleosides, bis-triazolyl derivatives, X-ray analysis
Cīrule, D., Ozols, K., Novosjolova, I., Turks, M., Bizdēna, Ē. A Synthetic Route to 2,6-Bis-triazolyl Purine Deoxynucleosides via Click Chemistry. No: Collection Symposium Series Volume 14. M.Hocek red. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. 233.-234.lpp. ISBN 978-80-86241-50-0.
Publikācijas valoda
English (en)