Synthesis of 6-T Rifluoromethyl Derivatives of 2-Arylamino-4-(Pyridin-3-Yl) Pyrimidines

Journal of Chemical Research 2015
S. Terentjeva, S. Muceniece, Viesturs Lūsis

The 6-trifluoromethyl derivative of a well known tyrosine kinase inhibitor, nilotinib, as well as some novel 6-trifluoromethyl substituted 2-arylamino-4-(pyridin-3-yl) pyrimidines were synthesised.

Atslēgas vārdi
2-arylamino-4-(pyridin-3-yl) pyrimidines; 4,4,4-trifluoro-1-(pyridin-3-yl)butane-1,3-dione; 4-(pyridin-3-yl)pyrimidines; 6-trifluoromethyl pyrimidines; n-aryl guanidines
DOI
10.3184/174751915X14273044526093
Hipersaite
http://stl.publisher.ingentaconnect.com/content/stl/jcr/2015/00000039/00000004/art00010

Terentjeva, S., Muceniece, S., Lūsis, V. Synthesis of 6-T Rifluoromethyl Derivatives of 2-Arylamino-4-(Pyridin-3-Yl) Pyrimidines. Journal of Chemical Research, 2015, Vol.39, No.4, 223.-225.lpp. ISSN 1747-5198. Pieejams: doi:10.3184/174751915X14273044526093

Publikācijas valoda
English (en)