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Publikācija: Development of Functionalized Hydroxyapatite/Poly(Vinyl Alcohol) Composites

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Nosaukums oriģinālvalodā Development of Functionalized Hydroxyapatite/Poly(Vinyl Alcohol) Composites
Pētniecības nozare 2. Inženierzinātnes un tehnoloģijas
Pētniecības apakšnozare 2.5. Materiālzinātne
Autori Līga Stīpniece
Kristīne Šalma-Ancāne
Vitālijs Rjabovs
Inna Juhņeviča
Māris Turks
Inga Narkevica
Līga Bērziņa-Cimdiņa
Atslēgas vārdi Microgranules; In situ synthesis; Spray drying; Hydroxyapatite; Poly(vinyl alcohol)
Anotācija Based on the well-known pharmaceutical excipient potential of poly(vinylalcohol) (PVA) and clinical success of hydroxyapatite (HAp), the objective of this work was to fabricate functionalized composite microgranules. PVA was modified with succinic anhydride to introduce carboxyl group s(–COOH), respectively, by reaction between the –OH groups of PVA and succinicanhydride, for attachment of drug molecules. For the first time, the functionalized composite microgranules containing HAp/PVA in the ratio of 1:1 were prepared through in situ precipitation of HAp in modified PVA aqueous solutions followed by spray drying of obtained suspensions. The microgranules were characterized by Fourier- transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and differential scanning calorimetry (DSC).
DOI: 10.1016/j.jcrysgro.2016.03.029
Hipersaite: http://www.sciencedirect.com/science/article/pii/S0022024816301087 
Atsauce Stīpniece, L., Šalma-Ancāne, K., Rjabovs, V., Juhņeviča, I., Turks, M., Narkevica, I., Bērziņa-Cimdiņa, L. Development of Functionalized Hydroxyapatite/Poly(Vinyl Alcohol) Composites. Journal of Crystal Growth, 2016, Vol.444, 14.-20.lpp. ISSN 0022-0248. Pieejams: doi:10.1016/j.jcrysgro.2016.03.029
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