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Publikācija: Natural-Antioxidant-Inspired Benzo[b]selenophenes: Synthesis

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Publikācijas valoda English (en)
Nosaukums oriģinālvalodā Natural-Antioxidant-Inspired Benzo[b]selenophenes: Synthesis, RedoxProperties, and Antiproliferative Activity
Pētniecības nozare 1. Dabaszinātnes
Pētniecības apakšnozare 1.4. Ķīmija
Autori E. Paegle
I. Domracheva
Baiba Turovska
M. Petrova
I. Kanepe-Lapsa
A. Gulbe
Edvards Liepiņš
P. Arsenyan
Atslēgas vārdi Benzo[b]selenophenes Antiproliferative Activity
Anotācija The cyclization of arylalkynes under selenobromination conditions, combined with an acid-induced 3,2-aryl shift, was elaborated as a general synthetic pathway for the preparation of polyhydroxy-2- and -3-arylbenzo[b]selenophenes from the same starting materials. The redox properties, free-radical-scavenging ability, and cytotoxicity against malignant cell lines (MCF-7, MDA-MB-231, HepG2, and 4T1) of the synthesized compounds were explored, and the obtained results were used to consider the structure–activity relationships (SARs) in these compounds. Consequently, the structural features that were responsible for the highly potent peroxyl-radical-scavenging activity were established.
DOI: 10.1002/asia.201600472
Hipersaite: http://onlinelibrary.wiley.com/doi/10.1002/asia.201600472/full 
Atsauce Paegle, E., Domracheva, I., Turovska, B., Petrova, M., Kanepe-Lapsa, I., Gulbe, A., Liepiņš, E., Arsenyan, P. Natural-Antioxidant-Inspired Benzo[b]selenophenes: Synthesis, RedoxProperties, and Antiproliferative Activity. Chemistry – An Asian Journal, 2016, Vol.11, No.13, 1929.-1938.lpp. e-ISSN 1861-471X. Pieejams: doi:10.1002/asia.201600472
ID 23464