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Publikācija: ε-Trimethyllysine Hydroxylase. Search of Inhibitors

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Publikācijas valoda English (en)
Nosaukums oriģinālvalodā ε-Trimethyllysine Hydroxylase. Search of Inhibitors
Pētniecības nozare 1. Dabaszinātnes
Pētniecības apakšnozare 1.4. Ķīmija
Autori Diāna Zeļencova
Edvards Liepiņš
Atslēgas vārdi ε-Trimethyllysine Hydroxylase (TMLH), computer modelling, Nuclear Magnetic Resonance (NMR)
Anotācija ε-Trimethyllysine hydroxylase (TMLH) is a homodimer enzyme that belongs to ferrous iron and 2-ketoglutarate dependent oxygenase family. Due to the lack of experimentally determined structure, the homology model of the TMLH enzyme was generated and optimized with the help of molecular dynamics. Afterwards it was used for the molecular docking calculations of the previously mentioned compounds. The developed docking protocol was successful in discriminating between active and inactive compounds.
Atsauce Zeļencova, D., Liepiņš, E. ε-Trimethyllysine Hydroxylase. Search of Inhibitors. No: Drug Discovery Conference: Abstract Book, Latvija, Riga, 27.-29. augusts, 2015. Riga: 2015, 166.-166.lpp.
Pilnais teksts
ID 24100