2,4-Diazidoquinazoline as Useful Starting Material in Heterocyclic Chemistry

XXII International Conference on Organic Synthesis: Scientific Program & Abstract Book 2018
Ērika Bizdēna, Svetlana M. Goliškina, Armands Sebris, Anatoly Mishnev, Māris Turks

It was discovered that 2,4-diazidoquinazoline in solution exists in a tautomeric equilibrium. The tetrazole – azide tautomerism of azidoquinazolines was studied since 1960s, however, its application for 2,4-derivatization of quinazolines is underexplored. For the first time the molecular structure of 5-(piperidin-1-yl)tetrazolo[1,5-a]quinazoline was proved by X-ray diffraction analysis. We have also shown that obtained 5-amino derivatives undergo CuAAC reaction with terminal alkynes to give novel quinazoline derivatives.

Atslēgas vārdi
2,4-Diazidoquinazoline, quinazoline, CuAAC, azido-tetrazolo tautomerism

Bizdēna, Ē., Goliškina, S., Sebris, A., Mishnev, A., Turks, M. 2,4-Diazidoquinazoline as Useful Starting Material in Heterocyclic Chemistry. No: XXII International Conference on Organic Synthesis: Scientific Program & Abstract Book, Itālija, Florence, 16.-21. septembris, 2018. Florence: 2018, P271.-P271.lpp.

Publikācijas valoda
English (en)