Calcium Phosphate Bone Cements for Local Vancomycin Delivery

Materials Science and Engineering C 2015
Dagnija Loča, Marina Putniņa, Jānis Ločs, Anastasija Smirnova, Zilgma Irbe

Among calciumphosphate biomaterials, calciumphosphate bone cements (CPCs) have attracted increased attention because of their ability of self-setting in vivo and injectability, opening the new opportunities for minimally invasive surgical procedures. However, any surgical procedure carries potential inflammation and bone infection risks, which could be prevented combining CPC with anti-inflammatory drugs, thus overcoming the disadvantages of systemic antibiotic therapy and controlling the initial burst and total release of active ingredient

Keywords
Calcium phosphate cement, PLA, Vancomycin, Microspheres, Drug delivery
DOI
10.1016/j.msec.2014.12.075
Hyperlink
http://www.sciencedirect.com/science/article/pii/S092849311400873X

Loča, D., Sokolova, M., Ločs, J., Smirnova, A., Irbe, Z. Calcium Phosphate Bone Cements for Local Vancomycin Delivery. Materials Science and Engineering C, 2015, Vol.49, pp.106-113. ISSN 0928-4931. Available from: doi:10.1016/j.msec.2014.12.075

Publication language
English (en)