Industry demands on cheap, full scale tactile sensors, capable to be embedded into material or structure being monitored. Previous research reported polyisoprene-nanostructured carbon black composite (PNCBC) as a promising material for this use. PNCBC is made when certain concentration of high-structure nano-size extra conductive carbon, close to that of a percolation threshold, is well dispersed into a rubber matrix before vulcanizing. In such case reversible piezo-resistance effect is observed. During previous research, it was concluded that technological parameters like mold pressure, vulcanizing time and filler distribution have a certain effect on final properties of PNCBC. In this work we have ascertained, how the concentration of filler and mold pressure during vulcanizing have an effect on mechano-electric properties of PNCBC. Extra conductive carbon black “Printex XE2” (“Degussa”) was mixed into polyisoprene matrix by means of cold rolls at room temperature. Afterwards the raw material was vulcanized using different mold pressures. Specific electric resistance and piezo-resistance effect were determined depending on filler concentration and mold pressure. The mechanism of the effect of processing parameters on the final sensor properties and the percolative behavior of PNCBC is discussed.