Carbon nanotubes offer attractive possibilities for developing new sensors because of superior mechanical and electrical properties. So far most studies relate the mechanical deformation to the change of nano-scale electrical properties. We present an attempt to use multi-wall carbon nanotubes (MWCNT) to develop a new flexible composite for macro-scale pressure sensors. Elastomer composites containing dispersed nano-size particles, for example, polyisoprene - multi-wall carbon nanotube composites,(PMCNTC) were prepared by treatment of the composite matrix with chloroform providing an increase of mobility and better dispersion of the nano-particles within the matrix. MWCNT with a small amount of solvent was carefully ground in a china pestle before adding to the polyisoprene matrix. Both the polyisoprene matrix solution and concentrated MWCNT solution were mixed in a mixer with small glass beads at room temperature for a certain time. The product was then dried and vulcanized under high pressure at 160ºC for 20 min.PMCNTC shows attractive pressure sensing properties. The highest sensitivity has been reached in the region slightly above the percolation threshold of the composite. The results are compared with the polyisoprene and high structure carbon black composites (PHSCBC) elaborated and prepared by a similar technology. A mechanism of the sensing effect is being discussed.