A New Pathway for the Preparation of Biologically Active 2-Substituted 1,5-Dihydrobenzo[E][1,2,4]Oxadiazepines and Related Compounds by Palladium-Catalyzed Cyclization of Amidoximes with O-Iodobenzyl Bromide or 2-Bromo-3-Chloromethylpyridine

ARKIVOC 2012
E. Ābele, L. Golomba, T. Beresneva, J. Visnevska, E. Jaschenko, I. Shestakova, A. Gulbe, S. Grīnbergs, Sergejs Beļakovs, R. Ābele

A simple palladium-catalyzed one-pot synthesis of 2-substituted 1,5-dihydrobenzo[e][1,2,4]- oxadiazepines from corresponding (E)-amidoximes and o-iodobenzyl bromide or 2-bromo-3- chloromethylpyridine is described. Of the derivatives prepared 2-[6-(quinolin-2-ylsulfanyl)- hexyl]-1,5-dihydrobenzo[e][1,2,4]oxadiazepine exhibits high activity on HT-1080 (hyman fibrosarcoma) and MG-22A (mouse hepatoma) cancer cell lines. Keywords:

Atslēgas vārdi
2-Substituted 1,5-dihydrobenzo[e][1,2,4]oxadiazepines, palladium catalyst, coupling, (E)-amidoximes, o-iodobenzyl bromide, 2-bromo-3-chloromethylpyridine
Hipersaite
http://www.arkat-usa.org/get-file/44444/

Ābele, E., Golomba, L., Beresneva, T., Visnevska, J., Jaschenko, E., Shestakova, I., Gulbe, A., Grīnbergs, S., Beļakovs, S., Ābele, R. A New Pathway for the Preparation of Biologically Active 2-Substituted 1,5-Dihydrobenzo[E][1,2,4]Oxadiazepines and Related Compounds by Palladium-Catalyzed Cyclization of Amidoximes with O-Iodobenzyl Bromide or 2-Bromo-3-Chloromethylpyridine. ARKIVOC, 2012, No.8, 49.-61.lpp. ISSN 1551-7004. e-ISSN 1551-7012.

Publikācijas valoda
English (en)