Evaluation of (E)-2-Chlorovinylsulfones as Novel Class of Cytotoxic Agents and Highly (E)-Stereoselective Addition of N-, S- And Se-Nucleophiles to (E)-2-Chlorovinylsulfones under Phase Transfer Catalysis Conditions
Heterocyclic Letters 2012
J. Višņevska, Sergejs Beļakovs, I. Shestakova, A. Gulbe, E. Jaschenko, E. Ābele

Novel phase transfer catalytic (PTC) method for the conjugate addition-elimination of N-, S- and Se-nucleophiles to (E)-2-chlorovinylsulfones has been developed. Products were isolated in yields up to 98%. (E)-2-Chlorovinylsulfones exhibit very high cytotoxicity against MG-22A and HT-1080 cancer cell lines


Atslēgas vārdi
2-chlorovinylsulfones; conjugate addition; phase transfer catalytic system; toxicity; cytotoxicity
Hipersaite
http://www.heteroletters.org/issue7/pdf/paper-1.pdf

Višņevska, J., Beļakovs, S., Shestakova, I., Gulbe, A., Jaschenko, E., Ābele, E. Evaluation of (E)-2-Chlorovinylsulfones as Novel Class of Cytotoxic Agents and Highly (E)-Stereoselective Addition of N-, S- And Se-Nucleophiles to (E)-2-Chlorovinylsulfones under Phase Transfer Catalysis Conditions. Heterocyclic Letters, 2012, Vol. 2, No. 3, 245.-252.lpp. ISSN 2231-3087. e-ISSN 2230-9632.

Publikācijas valoda
English (en)
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