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Publikācija: Structural Characterization of Cevimeline and Its Trans-Impurity by Single Crystal XRD
| Publikācijas veids | Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē |
|---|---|
| Pamatdarbībai piesaistītais finansējums | Nav zināms |
| Aizstāvēšana: | , |
| Publikācijas valoda | English (en) |
| Nosaukums oriģinālvalodā | Structural Characterization of Cevimeline and Its Trans-Impurity by Single Crystal XRD |
| Pētniecības nozare | 2. Inženierzinātnes un tehnoloģijas |
| Pētniecības apakšnozare | 2.5. Materiālzinātne |
| Autori |
Dmitrijs Stepanovs
Zenta Tetere Irisa Rāviņa Viktors Kumpiņš Daina Zicāne Ērika Bizdēna Janis Bogans Irina Novosjolova Agnese Ābele Remo Merijs-Meri Juris Fotins Maksims Čerkasovs Anatolijs Mišņovs Māris Turks |
| Atslēgas vārdi | Cevimeline, trans-Cevimeline, Impurity standard, Single crystal, X-ray analysis, Thermal analysis, Solubility |
| Anotācija | Cevimeline is muscarinic receptor agonist which increases secretion of exocrine glands. Cevimeline base is a liquid (m.p. 20–25◦C) at ambient conditions, therefore its pharmaceutical formulation as asolid hydrochloride hemihydrate has been developed. The synthesis of cevimeline yields its cis- and trans-isomers and only the cis-isomer is recognized as the API and used in the finished formulation.In this study structural and physicochemical investigations of hydrochloride hemihydrates of cis- and trans-cevimelines have been performed. Single crystal X-ray analyses of both cis- and trans-isomers of cevimeline are reported here for the first time. It was found that the cis-isomer, the API, has less dense crystal packing, lower melting point and higher solubility in comparison to the trans-isomer. |
| DOI: | 10.1016/j.jpba.2015.11.006 |
| Hipersaite: | http://www.sciencedirect.com/science/article/pii/S0731708515302260  |
| Atsauce | Stepanovs, D., Tetere, Z., Rāviņa, I., Kumpiņš, V., Zicāne, D., Bizdēna, Ē., Bogans, J., Novosjolova, I., Grigaloviča, A., Merijs-Meri, R., Fotins, J., Čerkasovs, M., Mišņovs, A., Turks, M. Structural Characterization of Cevimeline and Its Trans-Impurity by Single Crystal XRD. Journal of Pharmaceutical and Biomedical Analysis, 2016, Vol.118, 404.-409.lpp. ISSN 0731-7085. Pieejams: doi:10.1016/j.jpba.2015.11.006 |
| Papildinformācija |
Citējamību skaits: |
| ID | 21095 |
