Studies of Substituent Influence on Physical-Chemical Properties and Biological Activity in a Series of Cationic 1,4-Dihydropyridines as Gene Delivery Agents
Abstact Book of European Nanomedicine Meeting
2015
Klāvs Pajuste,
Kārlis Pajuste,
Oksana Petricenko,
Martins Rucins,
Aleksandra Vezane,
Irena Timofejeva,
Brigita Cekavicus,
Marina Gosteva,
Māra Plotniece,
Dace Tirzīte,
Brigita Vīgante,
Arkadij Sobolev,
Tatjana Kozlovska,
Aiva Plotniece
New group of 1,4-DHP amphiphiles as putative gene delivery agents with variations of the substituents at the molecule have been designed and synthesised. It can be concluded that structure of substituents of at positions 2 and 6 of 1,4-DHP molecule are important for radical scavening properties.
Atslēgas vārdi
1,4-DHP, gene delivery agents
Pajuste, K., Pajuste, K., Petricenko, O., Rucins, M., Vezane, A., Timofejeva, I., Cekavicus, B., Gosteva, M., Plotniece, M., Tirzīte, D., Vīgante, B., Sobolev, A., Kozlovska, T., Plotniece, A. Studies of Substituent Influence on Physical-Chemical Properties and Biological Activity in a Series of Cationic 1,4-Dihydropyridines as Gene Delivery Agents. No: Abstact Book of European Nanomedicine Meeting, Francija, Grenoble, 7.-9. decembris, 2015. Maison Minatec -Grenoble: 2015, 24.-24.lpp.
Publikācijas valoda
English (en)