Porous Hydroxyapatite for Drug Delivery

2015
Dagnija Loča, Jānis Ločs, Arita Dubņika, Vita Šteinberga, Līga Bērziņa-Cimdiņa

The disadvantages of systemic drug therapy are that only a small fraction of any given dose actually reaches the surgical site, producing low-therapeutic tissue levels. An alternative approach is based on the use of implantable delivery tools, able to release the active substance in a controlled way. Biocompatibility, bioactivity, and osteoconductivity are the main driving forces of calcium phosphate biomaterials, promoting their application as bone substitutes. At the same time, multimodal porous structure and interconnectivity of pores make them promising candidates for site-specific drug delivery. The use of porous hydroxyapatite as a drug delivery system could result in a dual effect: the ability to interact with the bone tissues at the same time ensuring increased drug efficiency, controlled release, and site-specific delivery.

Keywords
Calcium phosphates; Drug delivery; Porous hydroxyapatite
DOI
10.1016/B978-1-78242-033-0.00009-2
Hyperlink
http://www.sciencedirect.com/science/article/pii/B9781782420330000092

Loča, D., Ločs, J., Dubņika, A., Zālīte, V., Bērziņa-Cimdiņa, L. Porous Hydroxyapatite for Drug Delivery. In: Hydroxyapatite (HAp) for Biomedical Applications / ed. by M.Mucalo. Amsterdam: Elsevier, 2015. pp.189-209. ISBN 978-1-78242-033-0. e-ISBN 978-1-78242-041-5. Available from: doi:10.1016/B978-1-78242-033-0.00009-2

Publication language
English (en)