Lidocaine Loaded Hydroxyapatite Scaffolds for Bone Regeneration and Local Drug Delivery
9th International Conference on Global Research and Education: Inter-Academia 2010
2010
Dagnija Loča,
Jānis Ločs,
Juris Gulbis,
Ilze Šalma,
Līga Bērziņa-Cimdiņa
An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) porous scaffolds containing 4-5 mg lidocaine were prepared, lidocaine release rate was investigated and compared for scaffolds with and without biocompatible polyvinyl alcohol (PVA) coating. The in vitro dissolution tests showed 77% drug release within the first hour for uncoated scaffolds, while scaffolds with PVA coating released 67% of lidocaine within 7 h.
Keywords
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Loča, D., Ločs, J., Gulbis, J., Šalma, I., Bērziņa-Cimdiņa, L. Lidocaine Loaded Hydroxyapatite Scaffolds for Bone Regeneration and Local Drug Delivery. In: 9th International Conference on Global Research and Education: Inter-Academia 2010, Latvia, Rīga, 9-12 August, 2010. Riga: RTU Publishing House, 2010, pp.128-129. ISBN 978-9934-10-046-8.
Publication language
English (en)